At first I thought it was a cold.
Unexpectedly, the disease progressed fiercely.
Multiple organ failure …
It has something to do with chlamydia abortus.
Repeated fever thought it was a cold.
But there was multiple organ failure
Recently, Ms. Du (a pseudonym), who lives in Panyu District, Guangzhou, developed fever for three consecutive days, with a temperature above 39 degrees Celsius, accompanied by symptoms such as cough, dizziness and limb weakness.
At first, Ms. Du thought she had a cold, so she took cold medicine herself, but her symptoms did not improve and she still had repeated fever. Then she went to Panyu Central Hospital affiliated to Guangzhou Medical University for treatment. Chest X-ray examination results indicate "double lung infection", and the outpatient department plans to admit "pneumonia" to the infection department for hospitalization.
On the second day of admission, Ms. Du’s condition deteriorated rapidly, sweating profusely, irritability, shortness of breath, and blood oxygen saturation once dropped to 80% (more than 95% normal), and she was transferred to the intensive care department for further treatment.
However, Ms. Du’s condition continued to deteriorate, with shock, multiple organ failure and dying.
The team decided to start the VV-ECMO support treatment immediately, and put the tube on the machine quickly. Subsequently, Ms. Du’s whole body oxygen supply was improved and her vital signs tended to be stable.
Rare!
Finally diagnosed as "Chlamydia abortus"
High fever occurs in a short period of time, lung CT inflammation is mainly consolidation, and the disease progresses fiercely, resulting in multiple organ failure …
Which pathogen is the "murderer"? How to find out the "murderer"? It was found by the second generation sequencing technology of metagenome (mNGS) that the detection results of mNGS in alveolar lavage fluid and blood of Ms. Du indicated "Chlamydia abortus".
The rare results surprised everyone and provided important clues to the medical team. The medical team immediately adjusted the anti-infection plan according to the characteristics of chlamydia abortus and strengthened the organ function support treatment. After 7 days of treatment, Ms. Du’s condition gradually improved, and she was successfully separated from the ventilator, removed the tracheal intubation, and quickly transferred to the general ward for further treatment.
What is chlamydia abortus?
How to prevent it?
Chlamydia abortus is a prokaryotic microorganism parasitic in Gram-negative cells. Its main hosts are sheep, cattle, pigs, etc. Infected domestic animals will miscarry in the third trimester of pregnancy.
Studies have shown that chlamydia abortus can infect humans through respiratory tract transmission or direct contact, causing atypical pneumonia and abortion of pregnant women, and it is a zoonotic pathogen. Human beings can be infected by inhalation through respiratory tract or close contact with sick cattle and sheep. But human-to-human transmission is relatively rare. Ms. Du may have been infected by touching slaughtered cattle, sheep and pigs in the kitchen.
According to Jin Ju, deputy chief physician of the first district of the Department of Critical Care Medicine, Chlamydia abortus is usually considered to cause abortion, stillbirth and septicemia of pregnancy in human pregnant women, but it rarely causes human pneumonia.
He emphasized that for chlamydia abortus infection, prevention should be given priority, and immunity should be enhanced and personal hygiene should be paid attention to. Employees who have frequent contact with cattle and sheep should pay attention to environmental hygiene and take good health protection measures. If they have repeated symptoms such as high fever, chills, chills and dyspnea, and have a history of contact with poultry and livestock, and can’t find other reasons, they should go to the hospital in time and take the initiative to inform the doctor about the relevant contact history so as to take targeted treatment as soon as possible.
Transfer from: Guangzhou Daily
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