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Davidson ＂brushes existence＂？ The purpose of creating the concept of ＂Indo-Pacific＂ by the US is not pure.

　　Cctv newsOn May 30th, local time, US Secretary of Defense james mathis announced that the US Pacific Command was officially renamed Indian Ocean-Pacific Command. At the same time, Philip Davidson, a four-star general of the US Navy, also took office on the same day, replacing retired Harris as the first commander of the Indo-Pacific Command and officially taking over the United States, the world’s largest war zone that spans half the world. It is also a name change and a coaching change. What is the intention of this intensive action in the United States?

　　Defense Minister Matisse presided over the handover ceremony.

　　On May 30, local time, the handover ceremony of the US "India-Pacific Command" was held in Pearl Harbor, Hawaii. The ceremony was presided over by US Secretary of Defense Matisse, and the first commander Philip Davidson and other US naval officials attended. In addition to announcing the official name change, Matisse also clearly declared that the name change was due to the growing ties between the Pacific Ocean and the Indian Ocean, which symbolized the determination and commitment of the United States to the Indian Ocean-Pacific region.

　　News link: US Indian Ocean-Pacific Command

　　In the global military strategy of the United States, the Indo-Pacific Command plays an important role. The U.S. Pacific Command is one of the six major U.S. theater commands in the world, and it is also the largest one. The headquarters of the Indo-Pacific Command is located in Hawaii. Its predecessor, Pacific Command, is the earliest, largest and most extensive joint operations command of the US military. It has nearly 375,000 soldiers and civilians, and the Pacific Fleet alone has 130,000 troops and about 200 ships and nearly 1,100 aircraft including five aircraft carrier battle groups.

　　Davidson, the first commander, once said "brush existence"

　　It is widely speculated that the position of the first commander Davidson may be tougher than that of his predecessor. Because before, when Davidson appointed the hearing, he openly expressed the desire of the United States for influence in the Indian Ocean and Pacific region.

　　Davidson, 58, the first commander of the U.S. Indo-Pacific Command, served in the U.S. surface naval forces for a long time. Earlier, when attending the appointment hearing in the Senate, Davidson said that after taking office, the US military presence in the Indian Ocean and the Pacific region will be adjusted, and the priorities include strengthening the US military deployment in the region, arms upgrading, operational preparation, and power projection.

　　According to American media reports, Davidson believes that the troops deployed in the forefront of the Indo-Pacific region and the rotation troops are insufficient, and the current force structure and deployment situation are "not enough to deal with the threats in the Indo-Pacific region." He also claimed that the US military should continue to be committed to equipping a new generation of weapons, such as long-range hypersonic weapons. Observers believe that Davidson’s position may be tougher than that of Harry Harris, the former commander of the Pacific Command, who is regarded as the "hawk" of the US military’s Asia-Pacific policy.

　　News link: The concept of "Indo-Pacific" made by the US has a long history.

　　In fact, the idea of the United States relocating the so-called "Indian Ocean-Pacific" war zone has a long history.

　　In October last year, Tillerson, then US Secretary of State, repeatedly replaced the word "Asia-Pacific" with "Indo-Pacific" in public, and declared that the United States needed to strengthen cooperation with all parties in the region; In November last year, at the Asia-Pacific Economic Cooperation (APEC) Summit held in Da Nang, Vietnam, the word "Indian Ocean-Pacific" almost became one of the most important keywords in his speech. In many subsequent public occasions, senior officials of the US government frequently used the so-called "Indo-Pacific" concept.

　　At the same time, not long ago, according to the website of the US Military Times, the Armed Services Committee of the US House of Representatives stressed in a 15-page outline of the 2019 National Defense Act that it is necessary to "pass the so-called ‘ Indian Ocean-Pacific Stability Plan ’ Provide funds for the Ministry of National Defense to plan and provide necessary troops, military infrastructure and logistics capabilities in the region. The bill also calls for enhancing "awareness of maritime safety and marine areas in the Indian Ocean".

　　At the same time, not long ago, according to the website of the US Military Times, the Armed Services Committee of the US House of Representatives stressed in a 15-page outline of the 2019 National Defense Act that it is necessary to "pass the so-called ‘ Indian Ocean-Pacific Stability Plan ’ Provide funds for the Ministry of National Defense to plan and provide necessary troops, military infrastructure and logistics capabilities in the region. The bill also calls for enhancing "awareness of maritime safety and marine areas in the Indian Ocean".

　　Foreign Ministry of China: The United States should exist in the Asia-Pacific region in a responsible manner.

　　At the regular press conference of China’s Foreign Ministry yesterday, Foreign Ministry Spokesperson Hua Chunying also responded that no matter how the name is changed or called, the United States should exist in the Asia-Pacific region in a responsible manner and play a constructive role in regional peace and stability.

The movie ＂The Lie Detector＂ only scored 2.7 points. Mary, you are very dangerous!


Special feature of 1905 film network As the saying goes, "a thief cries to catch a thief" is often also a "liar", especially for the film quality — — The film "Lie Detector" was released for 3 days, and Douban scored 2.7 points, which set a new low for the starring career score.


And this, from the last time Mary was dominated by bad movies, only three months have passed. In the fierce competition and frequent masterpieces this year, there is a movie whose reputation and rating seem so out of place. Yes, that’s her starring, and Douban scored 3.8.


Let’s go back to the lie detector. The trio of Mary,, and makes people think of another film a few years ago. Although other actors are different, they have the same low score.


At this moment, in this situation, a question quietly welled up in my mind: Mary, what’s wrong with you?

Sit tight in a comedy movie, doesn’t it smell good?


Since 2004, Mary has performed thousands of plays, and made her debut on the stage of the Spring Festival Gala with her sketch "Today’s Happiness 2". Since then, she has become a frequent visitor to the Spring Festival Gala, and has firmly held the position of Hua Dan, the master of Mahua FunAge, and the queen of stage plays.


In 2015, Mary’s Shen Ma teamed up with Douban, a high-scoring comedy film, and won the National Day title with a price of 1.448 billion yuan, which achieved a win-win situation at the box office. Mary herself was highly praised for her role as Ma Dongmei and won the title of "national daughter-in-law". She integrates humor and sincerity into the role, and leads the audience to find true love in laughter and tears with humorous performances that break through the image.


Two years later, while the iron was hot, Shen Ma once again took the title of the National Day file with a box office of 2.213 billion yuan, which also made Shen Ma take the position of a brother and a sister in domestic comedy.


A year later, Mary’s opera road has undergone a "subversive" change. In the remake of the film, she successfully played a strong woman who appeared to be vigorous and vigorous, but in fact she encountered Han Xiao, a victim of sexual assault in the workplace, and completed the film’s reflection on relevant social issues. As a result, Mary, whose expression became more and more serious on the big screen, kicked off the transition from "a comedy sister" to "a strong injured woman".


As Mary said in an interview with the film channel, "Comedy lets the audience know that there is an actress named Mary, and they think you are a comedian. It seems that all your next works must be related to comedy, but I am an actor, and you should create different types of roles as an actor."


Mary’s road to transformation started here, but it seems that the screenwriter is convinced of Mary’s role as a "strong woman", which makes this image of strong appearance and inner pain continue to this day — — Sunshine in "Sunshine Robber" has a childhood shadow of being ashamed of his mother, while Ma Xiaofan in "Lie Detector" has a heart that has been hurt by love. After a long illness, he became a doctor, and both of them were strong because of their injuries, and they suddenly became strongmen. However, this series of images are too repetitive with Han Xiao in "The Ring of Calls", so the market recognition has been declining all the way.


On the contrary, in the field of comedy that Mary is familiar with, her unique performance style of "Northeast Mary" and more professional team production have produced a series of comedy actresses who are loved by everyone but have their own characteristics. The most recent example is the chapter of Liang Ma, which was released in the National Day in 2020. On the vast black land, Shen Ma performed a scene of "Variations on Country Love" belonging to Mahua FunAge, and it also became a comedy in the five chapters of the film.


Coincidentally, Mary’s new comedy, which has not yet been released, also won the best film in Golden Goblet Awards at the 24th Shanghai International Film Festival this year, which is undoubtedly an excellent way for her to transform from a word-of-mouth actress to an art award winner.


So the question is, should Mary transform?


Play a role well all your life. Is there a problem?


It is true that while jumping out of the "comfort zone", Mary has also completed the new image challenge and broken through himself, but it has also exposed a reality — — Not suitable for all roles. From the current point of view, the most suitable is the comedy heroine with a "Northeast Mary" style. Fortunately, this position has not been shaken so far.


Since at this stage, Mary’s transformation is not the best choice, then, do actors really need to transform?


The most obvious example is Mary’s old partner, Shen Teng, who has honed the years from "military school grass" to "the first brother of China comedy movies" with a wrinkled face. He made his debut in the Spring Festival Evening at the age of 33, won the first season championship of "Happy Comedy" in one fell swoop three years later, and became famous all over the country with "goodbye mr. loser". Since then, he has starred in four phenomena of "Shameful Iron Fist" in succession. And successfully cooperated with Mary in last year’s My People My Homeland, and performed Shen Guanglin in this year’s Spring Festival file perfectly. Not only did he sit firmly on the throne of comedy, but he also partnered with who was popular, so the key point came — — Did he change his career? Has he changed? No, but he has become a contemporary "king of comedy".


After the actor, let’s talk about an actress who has a stable performance — — On the road of temperament, I am unique. As soon as she made her debut, she won the Golden Rooster and Hundred Flowers Best Supporting Actress awards with Beautiful Feet, and she was once addicted to the stage of drama performance. Since 2014, she has been waiting for the screen works to leave a glimpse. In the star-studded performance of the National Day in 2019, she stood out as the captain of the crew who was calm and resolute, and won two female matches, Baihua and Jinji, in succession last year.


Of course, being a successful actor is not a "stable" success. For example, actresses who were born in comedies in their early years have already successfully transformed into realistic actresses with their works. Only when a handsome actor ignores the image can he successfully transform into an actor in art cinema. In the early years, it was a jade-faced young man in the mainland, and in the middle of 2015, he was reborn with his unkempt father role, and finally kept the cloud open in the TV series "Chasing the Murder in a White Night", "Angry Xiangxi" and "Longling Mystery Cave".


If Pan Yueming was at a low point in his life and career, it needs to be transformed urgently; Hugh has accumulated a lot of money, and everything is only due to the east wind; Yao Chen and other actresses have a long-term vision and make the right changes and decisions at the right time.


For an actor, it is very rare to be able to play a role well all his life (such as a special actor who plays a great man, an actor with tough guy style, or "Oriental Chaplin" atsumi kiyoshi who plays Torajiro all his life and creates the most "longevity" comedy series in film history). If it is really necessary to change the stage, it is not too late to change it. It is not necessary to change it for the sake of change. If everything is not available, not only will the "East Wind" not be obtained, but it will also be.


Seven departments, including the Ministry of Industry and Information Technology, issued documents to promote future industrial innovation and development.

　　The reporter learned from the Ministry of Industry and Information Technology on the 29th that seven departments, including the Ministry of Industry and Information Technology, the Ministry of Education and the Ministry of Science and Technology, jointly issued the "Implementation Opinions on Promoting Future Industrial Innovation and Development" (hereinafter referred to as the "Opinions") to strengthen the forward-looking planning and policy guidance for future industries, support the promotion of new industrialization, and accelerate the formation of new quality productivity.

　　"At present, the integration of scientific and technological innovation and industrial development is deepening, which has spawned the development direction of new industries such as metauniverse, humanoid robot, brain-computer interface and quantum information. Vigorously cultivating future industries has become a strategic choice to lead scientific and technological progress, drive industrial upgrading, open up new tracks and shape new quality productivity." The relevant person in charge of the Ministry of Industry and Information Technology said that China has comprehensive advantages such as complete industrial system, huge industrial scale and rich application scenarios, which provides rich soil for future industrial development, but at the same time, China’s future industrial development also faces problems such as insufficient system planning and weak technical base.

　　The Opinions put forward development goals in terms of technological innovation, product breakthrough, enterprise cultivation, scene development and industrial competitiveness: by 2025, China’s future industrial technological innovation, industrial cultivation and safety management will develop in an all-round way, and some areas will reach the international advanced level, and the industrial scale will increase steadily. We will build a number of future industrial incubators and pilot areas, break through hundreds of cutting-edge key core technologies, form hundreds of landmark products, and initially form a future industrial development model that conforms to China’s reality. By 2027, the comprehensive strength of the future industry will be significantly improved, and some areas will achieve global leadership. Major breakthroughs have been made in key core technologies, and a number of new technologies, new products, new formats and new models have been widely applied, forming a long-term mechanism for sustainable development and becoming an important source of future industries in the world.

　　The core of future industrial development is the innovation breakthrough of cutting-edge technology. According to the idea of "technological innovation-forward-looking identification-achievement transformation", the Opinions put forward specific measures to promote the industrialization of cutting-edge technologies: First, grasp innovation. Facing the six key directions of future manufacturing, future information, future materials, future energy, future space and future health, we will implement major national science and technology projects and major scientific and technological research projects, give play to the role of various innovation carriers, encourage leading enterprises to take the lead in setting up innovation consortia, and systematically promote key core technology research. The second is fine identification. Build a future industrial observatory, track the development trend of science and technology in key areas, focus on frontier hotspots, and use artificial intelligence, advanced computing and other technologies to accurately identify technological innovations with high-level technological breakthroughs and high-potential industrialization prospects. The third is to promote transformation. Regularly publish the catalogue of cutting-edge technology promotion, build an "online publishing hall" for future industrial achievements at a high level, build a product trading platform, hold an exhibition of achievements docking, and provide accurate docking. Build a high-level technology market and technology business incubator, efficiently integrate innovative superior resources, and promote the transformation of advanced scientific and technological achievements.

　　Specifically, the "Opinions" proposes to give play to the role of national strategic scientific and technological strength and leading enterprises in strengthening technology supply, accelerate breakthroughs in cutting-edge technologies and disruptive technologies, and create a source of original technologies. In terms of creating iconic products, we will break through the next generation of intelligent terminals, and develop industrial terminals that adapt to the trend of general intelligence, consumer-grade terminals that face the new needs of digital life, intelligent medical and health terminals that are suitable for the elderly, and super terminals with explosive potential; Do a good job in information service products, develop the next generation operating system, and promote open source technology; Strengthen the high-end equipment in the future and break through products such as humanoid robots and quantum computers. In terms of enriching application scenarios, we will accelerate the promotion of emerging scenarios such as the industrial metauniverse and bio-manufacturing, and rely on major engineering and project scenarios such as manned spaceflight and deep sea to accelerate the exploration of innovative applications of achievements in the future space direction. In optimizing the industrial support system, we will implement the pilot project of new industrial standardization, make overall arrangements for the future development route of industrial standardization, and speed up the development of key standards; We will further promote the construction of 5G, computing infrastructure, industrial Internet, Internet of Things, Internet of Vehicles and Gigabit optical networks, and build a new digital infrastructure that is ubiquitous, integrated, interconnected, intelligent, green, safe and efficient. (Reporter Cui Shuang)

　

　

　

　

Teach children math.

"A cabin is only 6 square meters. If you live in it, how will you decorate it?"


On December 25th, 2023, in the "Research and Practice Class of China Mathematicians Entering the Primary School Classroom" taught by Hua Yinglong, Vice President of Beijing No.2 Experimental Primary School, interesting questions deeply attracted the sixth graders.


The Mathematics Curriculum Standard for Compulsory Education (2022 Edition) points out: "The content design should reflect the application of mathematics in nature and society, show the great mathematicians in the history of mathematics development, especially the famous mathematicians in ancient and modern China, and the role of their mathematical achievements in the development of human civilization, and enhance students’ patriotic feelings and national pride."


It coincides with the 90th anniversary of the birth of Chen Jingrun, a famous mathematician in China. Hua Yinglong can’t help but think about the requirements of the curriculum standard: What kind of collision will happen when the world-famous China mathematician enters the primary school classroom? I want to chase the "brightest" star with my children!


Plant the seeds of curiosity


This class begins with the sharing of reading experience before class. Before class, the students previewed the reportage Goldbach conjecture in advance. In class, the students scrambled to share their feelings.


"Although some people discriminated against him, he didn’t waver in his love for mathematics. He was always calm, and his tolerant spirit was worth learning."


"I want to say to Chen Jingrun that you are really amazing. You were born in a family with no math environment, but you have made such achievements through hard work."


"What impressed me most was that Chen Jingrun studied hard in a 6-square-meter hut despite the difficult conditions."


…………


Students talked about being moved by Chen Jingrun’s spirit of studying and studying, and began to notice the mathematical element of "6 square meters" under the guidance of the teacher.


Hua Yinglong asked, "What kind of math topic do you think you can make up about the 6-square-meter hut?"


"Chen Jingrun’s room is 6 square meters, and their chimneys account for one-sixth of the room. How big is the living area?"


"The room is 6 square meters in total, and a chimney has cut the room into a corner, which is one-sixth of the room area. How big is this corner plus the total room area?"


…………


According to Hua Yinglong’s questions, the students expressed their opinions and collected five different proposition ideas. Hua Yinglong immediately gave his own examples. The students called "simplicity" and "logic", and an ordinary application problem set off a hearty "brainstorming" between teachers and students.


The reading method with "questioning" as the main guidance makes students experience the fun brought by mathematics reading, and guides students to think deeply and be eager to try after thinking.


After mastering more clues, students are more curious about the "6 square meter cabin". Hua Yinglong continued to ask: "What is a 6-square-meter cabin like?" He asked the students to draw a plan of the hut. With the help of students’ work sharing, Hua Yinglong has drawn out one enlightening question after another.


Through mathematics to restore the hut, children’s eyes look at the hut in a variety of ways: some are trapezoidal, some are square, some are marked with the position of the door and bed, and careful students mark the size of each layout …


"Teachers’ teaching design should read the world from a mathematical perspective, which is fascinating," Hua Yinglong said. "As a guide for students’ mathematics learning, we should plant a seed for them, hoping that one day, this seed will blossom a flower of’ everything counts’."


Bold trial and error in exploration


Around the "hut", Hua Yinglong took the students to solve the side length, and the "mathematical flavor" became stronger and stronger. At this time, a quick student confused the area and perimeter, and the students corrected his algorithm one after another. Hua Yinglong praised the student’s quick response and bold speech: "Children, in reading, not only reading, but also thinking. Every mistake is a reminder. We want to thank this classmate for reminding us." There was applause at the scene.


When calculating the side length of the hut, the students encountered a difficult problem-they had not touched the square root and could not continue to calculate.


"Children, we can’t make a square, can we still count?" Hua Yinglong asked. He didn’t impart knowledge beyond the outline, but left time for students to think. When a student tried repeatedly on the toilet paper and found the answer by reverse deduction, Hua Yinglong showed it to everyone with surprise and led them to summarize this valuable thinking process:


"Children, did this classmate try it right just once? No, he also found the answer by mistake, right? " Hua Yinglong once again guides students to correctly look at mistakes in learning. In such a class, students’ frustration tolerance is strong.


"Making mistakes is something everyone has to experience, including teachers." Hua Yinglong said, "We have to tell students that mistakes are often reminders, reminding us to calm down and think: Where is the problem? Why is it wrong? What new possibilities will there be? What new problems can you think about? "


"Where is the 6-square-meter hut and what is it really like?"


In order to give the child an accurate answer, Hua Yinglong shared his "journey to find the truth" after reading relevant books and materials, and went to the address of his former residence "No.88 Zhongguancun Street" in the materials to find out, but found that this was not the location of his mathematics institute. When I went to Fujian, I learned that there was a "Chen Jingrun Experimental Primary School" in the local area. I went there quickly, but I didn’t get the answer … Despite the twists and turns, with the help of Song Li, Chen Jingrun’s nephew, the real hut emerged a little bit: the room was square, and it became a "knife handle" shape after being occupied by the garbage passage. Because the space was narrow, people had to close the door before they could barely stand open …


Hua Yinglong’s exploration process of constantly trying to find a "real cabin" inadvertently set the best example for students.


Give students a bigger world.


"Students, suppose you enter Chen Jingrun’s cabin now, what do you want to say to him?"


As the class draws to a close, Hua Yinglong throws out the last question of this class. As early as in the open space next to the podium, he outlined the spatial structure of the hut with tape, suggesting that students take a walk in the "hut" and feel the living space of 6 square meters.


Some children bluntly said, "I love this mathematician very much, and I hope he will pay attention to his health and live in a big house." Some children felt "the sense of accomplishment gained by tireless knowledge" through repeated thinking, and some children called "Mr. Chen Jingrun is so great that in a difficult environment, he has confirmed the" Goldbach conjecture "that even the great mathematician Euler has not confirmed …


At this point, students’ feelings are not only the absorption after reading, but also the spiritual baptism after the classroom and teachers jointly verify and explore.


The students read the ten characters written by Hua Yinglong on the blackboard in unison-"A humble room grows into a superstar, and hardships make a great man". At that moment, the little boy seemed to have crossed time and space, ignorant and firmly paying tribute to the mathematician.


What can mathematics leave for students?


"A good math reading class is to give students reading energy and spiritual nourishment." Hua Yinglong replied in class, "I always think that education is humanized, which is the highest realm pursued by education." I am a primary school math teacher, but I don’t teach math. I use math to teach children. "

China Education News, January 5, 2024, 9th edition.　

80% of new drug data involved in false supervision has outstanding violations.

　　Since the State Food and Drug Administration started the self-inspection and verification of drug clinical trial data for one year, it has been found that over 80% of the clinical data of new drugs are involved in fraud, and the regulatory links behind them have fallen behind, and the violations of relevant subjects such as pharmaceutical companies, intermediaries and doctors are prominent.

　　Some people in the medical field believe that with the advance of the verification storm, negative arguments such as "too advanced" and "one size fits all" have risen. The state should adhere to zero tolerance for clinical fraud and reverse the medical ecology of bad money expelling good money with stricter supervision.

　　The enterprise intentionally concealed and omitted the records of adverse reactions.

　　The results of the verification of the authenticity and standardization of the data of 1622 drug clinical trial projects to be produced by the Food and Drug Administration caused a shock in the whole industry. Some people in the medical field revealed that with the deepening of self-examination and verification, more problems of untrue and irregular clinical trial data of drugs have been exposed. At present, over 80% of new drug applications have been withdrawn by pharmaceutical companies or rejected by the State Food and Drug Administration.

　　A staff member of the food and drug department said that during the verification, it was found that the clinical trial data of many drugs were incomplete, the analysis data had no differential trajectory, and some data could not be traced back. Other companies deliberately concealed or omitted the adverse reaction records, and revised the test data that failed to meet expectations.

　　"Before this round of self-examination and verification storm, clinical data fraud was an open secret in the industry." The dean of a top-three hospital in the west said that pharmaceutical companies randomly combined old drugs and found several hospitals to do clinical experiments. Of course, they all reported according to the expected results. Finally, the State Food and Drug Administration approved the new drugs. "How can this stew-style drug research and development model ensure the quality and safety of drugs?"

　　"The direct consequence of clinical data fraud is poor efficacy." A person in charge of research and development of a pharmaceutical company in Nanjing said that in a clinical trial, the company replaced the domestic anti-diabetic drug metformin taken by the subjects with the original drug Gehuazhi. Unexpectedly, after taking it for four weeks, the blood sugar of the subjects actually dropped to the level that they could not be enrolled in the group. Previously, the subjects had been taking domestic metformin, but their blood sugar could not be lowered.

　　According to insiders, most domestic generic drugs can’t meet the original research standards. In order to pass the evaluation, it is very common to conceal the discarded data and selectively use the data in clinical experiments. In this regard, the state launched the consistency evaluation of generic drugs’ quality and efficacy this year, requiring all generic drugs approved for marketing before October 1, 2007 to complete the consistency evaluation before the end of 2018, among which clinical effectiveness tests and varieties with special circumstances need to be carried out, and consistency evaluation should be completed before the end of 2021; If it is not completed within the time limit, it will not be registered again.

　　Yu Dechao, Chairman of Cinda Bio-Pharmaceutical, predicted that with the consistent evaluation of generic drugs’ quality and efficacy, more than 50% of the existing generic drugs will be eliminated, and the phenomenon of "bad money driving out good money" in the pharmaceutical field is expected to be initially reversed.

　　Absence of intermediary supervision encourages clinical fraud

　　In 1998, the relevant departments of the state promulgated the "Management Standard for Drug Clinical Trials (Trial)" (GCP for short), which was revised and implemented in 2003. The reporter’s investigation found that the binding force in the implementation of GCP is not strong, and the violations of relevant subjects such as pharmaceutical companies, intermediaries and doctors are prominent.

　　Driven by interests, some pharmaceutical companies have launched generic drugs, and the important and necessary link of clinical trials has been "ignored". The person in charge of a large pharmaceutical company in Jiangsu said that he had participated in the research and development of new drugs in a pharmaceutical company, in fact, he copied the newly developed innovative pharmaceutical materials from abroad. This pharmaceutical company spent a week preparing materials, and did not conduct clinical trials for six months at all. It even got the approval of "exclusive innovative drugs" very quickly. As a result, the effect of five domestic generic drugs is not obvious, but one foreign original drug is effective but can’t get in, which is a typical phenomenon of "bad money driving out good money".

　　The absence of supervision by CRO encourages the falsification of clinical data. A person in charge of a CRO revealed that CRO should be a third-party inspection agency, which plays a role in quality control of drug research and development, clinical application and approval. However, due to the lack of transfer threshold of domestic CROs and vicious competition of a large number of unscrupulous enterprises, many CROs have become accomplices in data fraud driven by interests. "Some pharmaceutical companies know that CRO is fraudulent, but considering that CRO shares the illegal costs and risks, they often turn a blind eye. What’s more, some pharmaceutical companies made it clear that if the test fails to pass the acceptance, it will not pay, forcing CRO to make fraud. "

　　A law enforcement officer of the food and drug supervision department said that during the inspection, it was found that the main body of clinical trials should be doctors, but some CROs hired a large number of assistant researchers instead of doctors to do clinical observation, data statistics and quality verification, which was an important reason for the irregular and untrue data.

　　Clinicians’ professional ethics is out of order, which opens the door for data fraud. The chief physician of a third-class hospital in Guangdong said that he had participated in the third-phase clinical trial of an obstetric drug under the leadership of another hospital. "The actual operation is not strict." Many records that are beneficial to the marketing of this drug have been saved, and adverse clinical cases or experimental data have been erased. Especially compared with similar drugs, the fraud situation is more prominent. "Doctors are very busy, clinical trials will not be done seriously, and there is no time to make such rigorous records. Many of them are done by CRO, and the authenticity is naturally greatly reduced."

　　Clinical supervision has become a weak link in the drug supervision system. Some people in the industry believe that drug regulatory authorities at all levels are generally short of regulatory talents and technical teams with clinical background, and long-term emphasis on system certification and neglect of clinical project process supervision, especially the safety and effectiveness evaluation of post-marketing drug clinical trials, and supervision is almost blank. A staff member of Jiangsu drug supervision system said that compared with GMP inspection team, there is a big gap in the ability of local clinical verification GCP team, and the personnel and technology can not keep up with the current requirements.

　　Beware of negative arguments weakening supervision.

　　The reporter’s investigation found that over the past year, the self-inspection and verification of drug clinical trial data has achieved remarkable results, initially curbing the situation of large-scale data fraud, and some pharmaceutical companies feel unprecedented pressure.

　　"In the past, there was almost no clinical supervision. Now we suddenly asked for self-examination and verification, which caught us off guard." A person in charge of a pharmaceutical company in Inner Mongolia complained that the storm of verification of clinical trial data was "a matter of punishing the Qing Dynasty with the laws of the Republic of China". The state’s policies can’t be changed constantly, and we can’t take the "opinions" and "regulations" issued today to consider what we did before.

　　The person in charge questioned why so many CRO companies were approved. Why did the test data provided by CRO company pass the review before? Why are clinical trial institutions approved by administrative departments not conducting regular trials? Why should the applicant bear most of the responsibility for a series of mistakes made by the regulatory authorities? "These problems need to be paid attention to by relevant management departments and explained reasonably."

　　Some people in the industry believe that there are two negative arguments to be vigilant against this unprecedented storm of clinical supervision. First, the introduction of policies should conform to China’s national conditions, and the requirements for innovation at this stage should not be too advanced; Second, the policy cannot be uniform, and some clinical data are just not standardized, not fraudulent, and should be allowed to exist.

　　Yu Dechao said that at present, it is a critical period to control "bad money drives out good money" in the field of drugs, and real innovation must be encouraged with the strictest system. Once the clinical fraud is spared, the result must be "a small gap becomes a big hole." "If a pharmaceutical company is allowed to falsify, then other pharmaceutical companies will follow suit. Therefore, we must adhere to zero tolerance and not relax about clinical fraud. "

　　In fact, compared with the United States, China’s drug supervision still needs to be strengthened. The State Food and Drug Administration has made it clear that if the clinical research data are fraudulent, the applicant’s new application for drug registration will not be accepted within three years, and the clinical trial data of the person directly responsible for participating in the research or organizing the research will not be accepted within ten years.

　　Dr Liao Guojuan, CEO of Suzhou Jinweizhi Biotechnology Co., Ltd. said that in the United States, once data fraud occurs, pharmaceutical companies and R&D personnel will be blacklisted and will not be allowed to enter related fields for life.

　　Insiders suggest that the country should actively integrate domestic pharmaceutical companies with the international market, establish an internal supervision system for pharmaceutical companies, and truly form core competitiveness through innovation in order to occupy a place in international competition.

Jiang Yan, the Goddess of Craftsmanship： Let China equipment reach a new height.

CCTV News:She is the first designer of ethylene compressor in China, breaking the long-term foreign technical monopoly; She created the first million-ton ethylene compressor in China and climbed to the peak of design technology in the same industry in the world. She is just an ordinary design director, but she leads the team to undertake 60% of the design tasks of the largest compressor manufacturer in China.

She is Jiang Yan, a professor-level senior engineer of Turbine Design Institute of Shenyang Blower Group Co., Ltd. During the historical journey of localization of major equipment, she worked hard and made great achievements, and became a veritable "dream catcher" for the industry to serve the country.

one

The birth of a miracle

After graduating from university in 1997, Jiang Yan stepped into the door of Shengu Group with great enthusiasm and became an ordinary designer. At first, she only made static equipment such as auxiliary machines, and was a "layman" of dynamic equipment such as compressors. After the research on the steering gear, she grew up from an ordinary technician to a senior engineer with her enthusiasm and amazing perseverance, and witnessed and participated in the technical progress of Shengu in the first line of design.

Ethylene, a compound composed of two carbon atoms and four hydrogen atoms, is one of the largest chemicals in the world, which constitutes more than 70% of petrochemical products. Its output is regarded as one of the important indicators to measure the development level of a country’s petrochemical industry.

Ethylene compressor can be called the "heart" of ethylene industry, and the million-ton ethylene compressor represents the highest level of petrochemical equipment. For a long time, the design and manufacturing technology of large ethylene compressors has been monopolized by a few countries.

In 2006, the state decided to build three million-ton ethylene projects in Tianjin, Zhenhai and Fushun. Shengu Group undertook the task of developing a million-ton ethylene compressor for these three projects. It is a historical opportunity that must be grasped to end the history of passive dependence on imports and get rid of the embarrassing situation of being controlled by others.

Jiang Yan was only 33 years old when he received the R&D task. Young, not good at talking, and not graduated from a famous university, can this seemingly soft and weak woman break through the "hard ice" that Chinese people have been trying hard for decades? If it can, it must be a miracle.

But miracles are always created by people.

After taking over the task and provoking the "burden", Jiang Yan and her colleagues shuttled between major refining and chemical plants in China day and night, climbing the workbench of imported ethylene plants with a height of tens of meters over and over again to observe the appearance structure and operation; Visit major scientific research institutes in China again and again, visit, consult and discuss; Study hard one after another thick original foreign language materials … … Design failure, modify the design, fail again and modify again. After unremitting efforts, Jiang Yan and her team redesigned the structure of the compressor and successfully put it into use.

At 18: 00 on February 22, 2011, the first domestic million-ton ethylene compressor was successfully tested in the assembly workshop of Shengu Group, which made China the fourth country in the world to independently design and develop million-ton ethylene compressors.

From 450,000 tons, 800,000 tons, 1 million tons to 120 tons, Shengu Group has accumulated more than 1,000 compressors so far, completely ending the passive situation of China’s long-term dependence on imports of ethylene compressors and directly saving the country 5 billion yuan in imported equipment funds. With the hard work of "Jiang Yan", developed countries have gone through 100 years in the field of ethylene compressor development, while China only took 10 years.

2

The goddess is a model worker and a mother.

Jiang Yan is famous for her diligence in the factory. On the day before her daughter was born, she still kept the habit of being the first to work in the office every day. It is this hard work that has won her the title of Shenyang Special Model Worker, Liaoning May 1st Women’s Advanced Individual, National May 1st Labor Medal and National Model Worker. On April 28th, 2013, as a representative of industrial workers in Shenyang, she spoke in the Great Hall of the People and was personally received by the General Secretary of the Supreme Leader.

The goddess model worker is an excellent female craftsman in the country, but she is also the wife and mother of a family.

In 2012, there was a problem with the compressor of a domestic enterprise. Jiang Yan, who just got off the plane from the scene and saw her husband, cried in a big mess. "At that time, I really thought, I hope something will happen on the plane, and I won’t have to worry about it the next day." Her lover has been patiently asking what happened. As a colleague, the husband can always detect his wife’s thoughts at the first time and slowly enlighten him. In Jiang Yan’s heart, her husband will always be his most solid backing.

Because of work, Jiang Yan owed too much to her daughter since she was a child. In 2013, my daughter was hospitalized with a bad cold. As a mother, she was unable to accompany her little daughter to take care of her because of the Huizhou project. There is still a short message from her daughter in her mobile phone: "Mom, I have been waiting for the bus in the snow for 40 minutes, but I have not come yet. I am freezing and crying. I miss you to pick me up."

Sometimes, after a long business trip, Jiang Yan took out her daughter’s photos on her mobile phone and looked at them. She said that her 14-year-old daughter is 1.7 meters tall, with good academic performance and independence. Having her is the greatest achievement and happiness in this life.

one

The craftsman heart of the goddess

In Jiang Yan’s mind, the so-called "great country craftsman" must "sit on the bench and keep an eye on the computer."

Jiang Yan’s design team is mostly young people born in 1980s and 1990s, with an average age of less than 30 years old. They are full of energy but not ostentatious, and they are practical and diligent. "Doing things one step at a time, walking too fast, you will feel empty one day." Jiang Yan said.

"Sister Jiang is the absolute guarantee of the project!" For apprentice Han Shuai, the customer named Jiang Yan to lead the design, which made him feel proud as an apprentice.

After 1985, Han Shuai officially worshipped Jiang Yan as a teacher in 2015. "Sister Jiang is a strong woman." He secretly rejoiced when he learned that he would become Jiang Yan’s apprentice. But it is this "female man" who is resolute in her work, but she treats her colleagues delicately and gently in her life. Han Shuai said, "In winter, if anyone’s home heater is broken, Sister Jiang will lend them her own electric heater."

Jiang Yan said frankly, in fact, I’m not just "Jiang Yan", but I’m representing 7,300 employees of Shen Gu who have made silent contributions in their posts. She believes that the craftsman spirit is more about loyalty to the enterprise and persistence in the profession. She said, I remember our leader said: "Ten years ago, when I visited a Japanese enterprise, I saw a craftsman grinding the weld. Ten years later, the old craftsman still stuck to his post and did the same job."

"Be sure to be practical!" This is the most important trait that Jiang Yan thinks as a craftsman, and this is also the evaluation of the model worker director by the young people in the design room of the Turbine Design Institute where Jiang Yan is located: "simple, practical and honest".

Jiang Yan said, "In the future, we will never be followers and imitators, but leaders and leaders. As ‘ Old advanced ’ Technical personnel of state-owned enterprises, I will aim at the forefront of world science and technology, shift our products from high-speed growth stage to high-quality development stage, and promote more ‘ Made in China ’ Trend ‘ China created ’ Make your own contribution to building an innovative country. " (Source: Yang Guangwang China Civilization Network)

Kunming Xingyue L price reduction news, the lowest price is 122,200! If you miss it, you won’t

[car home Kunming Preferential Promotion Channel] Recently, preferential activities in Kunming are under way. The maximum discount amount reached 15,000 yuan, and the minimum starting price was 122,200 yuan. If you are interested in Xingyue L, you may wish to click "Check the car price" in the quotation form to get a higher discount.

昆明星越L降价消息，最低售价12.22万！错过就没有

The exterior design of Xingyue L adopts the family-style design language of Geely Automobile, showing an overall luxurious style. On the front face, Xingyue L uses a large-area air intake grille with chrome decoration, which is very delicate. The headlights on both sides are sharp and integrated with the air intake grille, which increases the overall visual impact. The lines of the whole vehicle are smooth, and the waistline on the side of the body extends from the front fender to the tail, which enhances the dynamics of the body. At the rear of the car, Xingyue L adopts a penetrating taillight design with chrome trim to enhance the layering of the rear. On the whole, the design of Xingyue L is simple and atmospheric, and it has the temperament of a high-end model.

昆明星越L降价消息，最低售价12.22万！错过就没有

The body size of Xingyue L is 4770*1895*1689 mm, the wheelbase is 2845 mm, and the front and rear tracks are 1610 mm. The side lines of the car body are smooth, showing an atmospheric and steady shape. The car is equipped with 20-inch rims, compared with 245/45 R20 in tyre size. With the fashionable and dynamic rim design, the sense of movement and visual impact of the whole car are enhanced.

昆明星越L降价消息，最低售价12.22万！错过就没有

The interior design of Xingyue L highlights the perfect combination of technology and luxury. The 12.3-inch large screen on the center console not only improves the visual effect, but also integrates various functions such as multimedia system, navigation, telephone, air conditioning and skylight, and supports voice recognition control, so that drivers can operate easily. The steering wheel is wrapped in leather, which feels comfortable and supports manual adjustment up and down, forward and backward to meet the needs of different drivers. In terms of seats, the Xingyue L is made of imitation leather, and the main driver’s seat provides rich adjustment functions, including front and rear adjustment, backrest adjustment, height adjustment (4-way) and lumbar support (4-way), and is equipped with heating, ventilation and massage functions, as well as headrest speakers. The co-pilot seat also has the functions of front and rear and backrest adjustment. In addition, the front seats also have electric memory function, which is convenient for drivers to quickly adjust to the most comfortable position. The second row of seats supports backrest adjustment, and the rear seats can be laid down in proportion, providing flexible storage space. The car is also equipped with USB and Type-C interfaces to facilitate passengers to charge, and the front row is also equipped with wireless charging function to meet the needs of modern people for charging mobile phones.

昆明星越L降价消息，最低售价12.22万！错过就没有

Xingyue L is equipped with a 2.0T 238-horsepower L4 engine, with a maximum power of 175kW and a maximum torque of 350 N m. With an 8-speed automatic manual transmission, it provides a strong power output and a smooth driving experience for the vehicle.

Car home car owners’ evaluation of Xingyue L is: "The power space has excellent texture, and the appearance value is simple and atmospheric!" This fully shows the outstanding performance of Xingyue L in all aspects, which is impressive in terms of strong power, spacious space and excellent texture.

Cabbage price faw Toyota strikes 2.4T engine.

The design of Toyota 2000 Middle East Edition is very domineering, and the overall design style remains unchanged, but the changes in details make it more refined. The front face of the new car has changed a lot. The middle net still adopts a split design. The horizontal chrome trim on the upper part is very textured, and the headlight group on the lower part is also consistent with the cash, which looks very sharp as a whole.

Interior: The interior design is exquisite, the interior workmanship is relatively fine, the interior workmanship is relatively good, and the interior workmanship is very fine. The overall interior of this car feels very beautiful, very beautiful. I am the car at first sight, and I like the appearance. It looks particularly tall. The shape of the whole car is very beautiful and the lines are very strong.

The length, width and height are 4925×1980×1920mm respectively, and the wheelbase has reached 2850 mm. In the same class, the wheelbase of Prado ranks 109th. This size exceeds most models in its class. The actual interior space performance is also very good. From the actual ride experience, the front and rear rows are relatively spacious. The 6-seat skylight of Prado dual-engine 2.4T Hanno WX version provides a wider view, which can create a better visual environment and good sensitivity for the rear passengers and increase the light entrance for the whole vehicle. Among the models of the same price and class, Prado’s trunk volume ranks 161st. It can basically meet the luggage space for family travel. But there is no extra hidden storage space.

The 6 seats of Prado dual-engine 2.4T Hanno WX version adopt 2.4 engines, with a maximum horsepower of 282 and a peak torque of 430, matching the automatic manual transmission (AT). 2.4 The power performance of the engine on Prado is quite satisfactory, and the low torque is weak and the hysteresis can be felt. Ranked 23rd among more than 800,000 SUV models.

Prado’s active/passive safety configuration is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

If the above data and participation can’t fully understand Prado, then we can give you a more comprehensive reference based on the word-of-mouth information of users who have purchased Prado in history. It can be seen that what everyone is most satisfied with Prado is its sharp headlights. In addition, its high value and beautiful appearance are also the points that everyone likes it.

How is the price performance？ Toyota Fenglanda gave a minimum of 7.4 fold.

Many consumers think that the cost of buying a car plus the cost of maintaining a car every year is really a lot of money, but now taxi software is so popular that it is convenient and cheap to take a car, and it is not practical to buy a car. However, in bad weather such as cold or hot, carrying a heavy shopping bag or dragging a huge suitcase, or when the driver is in an emergency, he will feel the pain of waiting. Although cars are consumables, and even the rate of preservation is not high, there is no denying that owning a car of your own can really bring great convenience to life, such as going to go on road trip.

Today, we will take a look at this new car, Fenglanda, in terms of its design, rough interior and high and low performance. Presumably, small owners have dived into major forums and dug up numerous evaluation videos, so there is no need to repeat it in small series. Now, our focus is on the transaction price, discount, sales volume and value preservation of Fenglanda, so as to help small owners who are basically targeting and waiting for the opportunity to start judging whether it is worth winning.

This site has collected the real transaction price of Toyota Fenglanda in the past year. The lowest transaction price of Fenglanda in the country in the past month was 127,400 yuan, the highest cash discount for new cars was 34,200 yuan, and the maximum discount for new cars reached 7.40 fold! The price is for reference only, and the actual transaction price is subject to the local dealer.

Choose a car to buy a car? The difficulty of choosing a good car is almost catching up with the college entrance examination to fill in the volunteers! But in fact, it is not difficult to choose a car. It really depends on the sales volume. What everyone likes can’t be worse. Toyota Flanders sold 20,116 vehicles in the past month, and the consumer recognition of new cars in the market can be seen from the sales trend chart below.

Next, let’s take a look at consumers’ comments on Toyota Flanders. If the comprehensive score is 5, then Toyota Flanders’ score is 4.60, and the result is not bad.
Among them, Toyota Flanders have the most outstanding performance in appearance and fuel consumption, so consumers pay more attention to appearance and fuel consumption.
Then Toyota Fenglanda can focus on it.
Because each user has different needs for the car, different uses and different feelings, the evaluation is only for reference. The most reliable thing is to go to the store to test drive in person. Even if you can’t test drive on the road, you should sit in the car and feel it.

If you have seen the above, you still have doubts about whether Toyota Fenglanda is worth buying, then you can also look at the performance of competing products of Toyota Fenglanda. Among the following competing products, Geely Xingyue L, which sold the most last month, was 14,373 vehicles. There is always one car for you.

If the price of Fenglanda is right in the near future, then the friends will hurry! Linkage promotion in many places across the country, and there are even more discount models as low as 30%.

A shares continued to rise： 1 trillion yuan was traded in the two cities, and 3,874 shares closed up.

The turnover of the two cities was 1 trillion yuan, and 3,874 shares closed up.

The three major stock indexes of A shares opened lower collectively on March 20th. In early trading, the two cities fluctuated within a narrow range, and the rise of bank stocks before noon boosted the depressed two cities. In the afternoon, the two cities continued to fluctuate within a narrow range, but individual stocks showed a general upward trend.

From the perspective of the disk, the theme of artificial intelligence is stronger, and the direction of Sora and short drama leads the rise; Low-altitude economy, data elements, smart medical care and Xinchuang concept stocks are active; Liquor, household appliances and steel industries have weakened.

By the close of March 20th, the Shanghai Composite Index rose 0.55% to 3,079.69 points. The Science and Technology Innovation 50 Index rose 0.28% to 814.03 points; The Shenzhen Component Index rose 0.21% to 9717.37 points; The growth enterprise market index rose 0.12% to 1909.2 points.

Wind statistics show that 3,874 stocks in the two cities and the North Stock Exchange rose, 1,264 stocks fell, and 213 stocks were flat.

On March 20th, the total turnover in Shanghai and Shenzhen stock markets was 1,000 billion yuan, a decrease of 77.9 billion yuan compared with 1,077.9 billion yuan in the previous trading day. Among them, the Shanghai stock exchange traded 407.4 billion yuan, a decrease of 39.5 billion yuan from the previous trading day’s 446.9 billion yuan, and the Shenzhen stock exchange traded 592.6 billion yuan.

According to Great Wisdom VIP, there are 119 stocks in the two cities and the North Stock Exchange that rose by more than 9%, and one stock fell by more than 9%.

The total net inflow of northbound funds on March 20th was 5.568 billion yuan. Among them, Shanghai Stock Connect bought 2.56 billion yuan and Shenzhen Stock Connect bought 3.009 billion yuan.

Bank shares rose sharply before noon, and liquor led the decline.

In terms of sectors, bank shares soared before noon, with Bank of China (601988) and China CITIC Bank (601998) once rising by over 2%, Bank of Beijing (601169) and Shanghai Rural Commercial Bank (601825) rising by over 1%.

The outbreak of short drama theme led the media stocks to rise among the top, with nearly 10 stocks including Huace Film and Television (300133), Zhongguang Tianxuan (603721), Zhangyue Technology (603533) and Ciwen Media (002343) rising by more than 10%.

With three barrels of oil, the petroleum and petrochemical sector soared, with daily limit of Baoli International (300135), China Petroleum (601857) rising by nearly 2%, China Petrochemical (600028) and China Offshore Oil (600938) rising.

Liquor led the decline, and the food and beverage sector did not perform well, with Qinghai Spring (600381) falling more than 4%, Gan Yuan Food (002991), Yingjia Distillery (603198) and Angel Yeast (600298) falling more than 2%.

Household appliances were among the top losers, with Omar Electric (002668), Sanhua Zhikong (002050), Sichuan Changhong (600839) and Huaxiang (603112) falling more than 1%.

The communications and electronics sectors were in a downturn, with Obi Zhongguang (688322), Sanhuan Group (300408), Shenyu (300563) and Fiberhome Communications (600498) falling more than 3%.

Try to choose the opportunity of callback to intervene.

Guosheng Securities said that recently, the market started to gain momentum under the policy combination of management, and the overall index maintained an upward trend, which is also the direction selected by the market after two weeks of sideways shocks. Once the trend is formed, if you want to reverse it, you need more short-selling power. In the current market environment where short-selling forces are suppressed layer by layer, the probability of a sharp decline is small. Therefore, the best choice at the moment is to follow the trend, and short-term adjustment is a better entry layout point, which can actively seize the opportunity. Strategically, because the current market is dominated by plate rotation, the game of theme plate is weak, so it is necessary to pay attention to controlling the rhythm, try to choose the opportunity of callback to intervene, and choose the target with better overall trend as the right bargain-hunting layout. In the direction, we can pay attention to the trend layout opportunities of smart driving, consumer electronics and artificial intelligence.

Hualong Securities pointed out that, after the previous high dividend sector and the theme of scientific and technological innovation achieved good performance continuously, the market showed a certain degree of "high cutting and low cutting" phenomenon, which was mainly manifested in switching to the direction of low valuation and value. The medium and long-term high dividend and the theme of scientific and technological innovation remained the main line of the market, and in the second half of March, it paid attention to the possible opportunities in industries such as pharmaceutical biology, electronics, building materials, architectural decoration, power equipment, non-bank finance, machinery and equipment and related topics.

Central china securities believes that the average P/E ratios of the Shanghai Composite Index and the Growth Enterprise Market Index are 12.37 times and 30.57 times respectively, which are below the median level in recent three years, and the market valuation is still in a low region, which is suitable for medium and long-term layout. Boosted by many favorable factors, the overall stock index is expected to maintain a volatile pattern in the future, and it is still necessary to pay close attention to the changes in policy, capital and external factors. Investors are advised to pay short-term attention to investment opportunities in industries such as consumption, agriculture, animal husbandry, feeding and fishing, and resources.