Attention! ＂ADHD＂ can’t be equated with mischief.

　　When children suffer from a disease called "attention deficit and hyperactivity disorder" (hereinafter referred to as "ADHD"), many parents are still in the dark. On the surface, children are just active, unable to sit still, and even appear smarter than other children. Isn’t this the "nature" of children in the traditional concept?

　　In medicine, behind hyperactivity is that attention can’t be concentrated normally. Hyperactivity may decrease with the increase of age and self-control, but it is difficult to alleviate the defect of attention, which may affect children’s life in study, work and life.

　　The Second People’s Hospital of Guizhou Province (Guizhou Mental Health Center) opened a special outpatient clinic for children and adolescents with learning difficulties on March 6th this year. Over the past six months, it has received hundreds of cases of "ADHD" among adolescents, and carried out professional intervention treatment under the guidance of the expert team of attention deficit hyperactivity disorder in the Sixth Hospital of Peking University.

　　"ADHD" can’t be equated with mischief.

　　Medical "attention deficit and hyperactivity disorder" is often just hyperactivity or mischief in the cognition of many parents. "There are many sick boys, and children are often smarter and have high IQ." Xiong Jie, deputy director of the Women and Children Psychiatry Department of the Second People’s Hospital of Guizhou Province, said, "Many parents didn’t notice ‘ Move around ’ The attention deficit problem behind it. "

　　Many details in children’s life can be used to judge whether they have attention problems: whether children in kindergarten can concentrate on listening to a story told by their parents; When children draw, will they unconsciously turn their eyes from drawing paper to pen tip? Is it always a drag to finish the exercises … …

　　Other children will provoke their classmates lightly, and may draw a picture on their classmates when sharpening pencils; Can’t stand the constraints of classroom discipline and get along well with teachers and classmates; Parents who often fight are invited … … Qian Ying, deputy director of Peking University Sixth Hospital and Peking University Clinical Psychology Center, explained that "hyperactivity" is a dimension of attention deficit, and there are many subtle manifestations in patients’ study and life.

　　"There is something called dopamine in their brains that is not enough." Qian Ying made an analogy: "There seems to be a battle in the brain. When dopamine secretion is normal, the marshal in the brain can direct everything. When it is time to move, it should be quiet. If the dopamine secretion is less, the marshal may fall asleep and the soldiers will start to move uncontrollably. "

　　An article published in the Chinese Journal of Epidemiology in 2018 showed that the total prevalence rate of attention deficit and hyperactivity disorder among children in China was 5.6%, and subgroup analysis showed that the prevalence rate of boys was 7.7% and that of girls was 3.4%. Qian Ying said that less than 1/3 of the patients were formally treated, and the proportion of patients receiving formal treatment after treatment was even lower.

　　The reason why children fall behind in their grades may be the lack of concentration.

　　The reason why some teenagers really go to the hospital is that there is a problem in their learning status. After analyzing a large number of cases, it is found that the first and third grades of primary school are the peak periods for children to suffer from ADHD.

　　Xiong Jie’s children have just entered the first grade this year, and the teacher will ask Xiong Jie for advice: Why can’t some children in the class concentrate on the lecture anyway? This directly leads to their inability to keep up with their studies. "If six or seven-year-old children can only concentrate for a few minutes, they will definitely not be able to study normally." Xiong Jie said.

　　The study found that some sick children have high IQ, and they can not concentrate on each class for a long time in the first and second grades, but they can also learn some knowledge, and they can barely keep up with the learning progress by being smart. Generally, in the third grade, academic performance will drop significantly. At this time, if you don’t see a doctor again, by the sixth grade and junior high school, your child will face more serious problems. "It is often that academic performance is not good and interpersonal communication is not good. How do children find themselves unloved?" Qian Ying said that children will feel inferior because of this, and with the advent of adolescence, many children have a stiff relationship with their parents.

　　Qian Ying opposes that some parents often say that their children are too rebellious in adolescence. "In fact, the child is wronged in his heart. He can’t control himself, but there is something wrong with dopamine in his brain." Through contact with a large number of patients, Qian Ying found that if children at this time did not feel the warmth of teachers, classmates and relatives, and did not see a doctor in time, they were most likely to get into bad habits, such as indulging in the Internet, smoking, drinking and even committing crimes.

　　Xiong Jie and experts from the Sixth Hospital of Peking University once went to a drug rehabilitation center for investigation, and found that the proportion of drug addicts with ADHD in childhood was very high, and they basically did not receive professional intervention. Many people’s life trajectories are also surprisingly similar: from poor academic performance to behavioral problems, they gradually affect their emotions and appear personality defects, and then they are misled by others to further develop drug addiction … …

　　Professional treatment should be promoted to preschool age.

　　"Attention deficit and hyperactivity disorder" has the same obvious influence on a person as an adult.

　　Among the cases studied in Peking University Sixth Hospital, lateness and procrastination are the most common problems. Some patients have never been able to go to work on time, and serious "starting difficulties" have made him often criticized by leaders; Some patients are seriously procrastinating and incompetent, and are considered irresponsible by colleagues; Some people have serious emotional problems because of self-blame, and their social status as adults is very low, and they can’t keep up with their peers.

　　Some patients will show "high function". A doctoral student in Peking University, whose research ability is not weak, has been unable to start writing a thesis; A 40-year-old university teacher completed his knowledge accumulation by amazing self-discipline, but he had to make a particularly strict time schedule to complete his work. After becoming a doctoral tutor, he had to rely on drugs to improve his attention to complete his teaching and research tasks.

　　Qian Ying believes that to prevent similar problems in adulthood, it is necessary to intervene from an early age. One of her important research directions is preschool intervention. At present, the internationally accepted cognition is "early judgment, early action and active treatment". Qian Ying explained that this means that it is not necessary to make a diagnosis for preschool children with ADHD, but it is necessary to carry out professional intervention, especially non-drug intervention, as soon as possible.

　　Qian Ying was particularly pleased that after the opening of the adolescent learning disability clinic in the Second People’s Hospital of Guizhou Province for half a year, she had the first preschool child to see a doctor. Although the final diagnosis showed that the child was not ADHD, Qian Ying believed that this showed that parents in the western region began to sprout their understanding of the disease.

　　Qian Ying explained that people’s brains will be more mature when they reach a certain age, but people’s executive skills will last longer, and some people will continue to develop into adulthood. Some professional methods can be used to promote the development level of children with slow development of executive skills.

　　At present, Peking University Sixth Hospital and Shenzhen Children’s Hospital are jointly trying to intervene on "attention deficit and hyperactivity disorder" before school, and foreign professional researchers are also involved. Qian Ying found that after several months of training, some children made obvious progress. "The exact conclusion may be studied in five years." Qian Ying said.

　　Going to a mental health hospital for treatment is a difficult psychological hurdle to overcome.

　　In order to let more families know about the treatment knowledge of preschool ADHD, Qian Ying wrote a book on how to carry out family group training of executive skills, so that more parents can find problems, pay attention to them and make some active interventions for their children.

　　She believes that it is more important to let parents and children really sit in front of professional doctors, but the current embarrassment is that professional doctors often take their children into these places in mental health research institutions or "mental hospitals" that people often express, which is still difficult for many people.

　　Qian Ying noticed that some private early education institutions have set up children’s concentration training courses, and the fees are ten times or even dozens of times that of public hospitals. Many parents are willing to sign up their children. She believes that on the one hand, it is necessary to see that these institutions are mixed and there are no teaching standards, and the professionalism of teachers may not be qualified for the curriculum requirements; On the other hand, in the future, professional medical institutions can cooperate with educational institutions to integrate professional knowledge into the curriculum of kindergartens and schools, which will be more acceptable to children and parents.

　　WU GANG, director of the Women and Children’s Department of the Second People’s Hospital of Guizhou Province, also said, "I hope that professional outpatient clinics can drive more people to pay attention to the psychological problems of teenagers, and treat them as a cold." WU GANG plans to get a batch of professional diagnosis and treatment equipment for departments, send more medical staff to participate in professional study, and build a platform for cooperation with educational institutions and non-profit organizations in the future, so as to drive away the "sense of shame" under old ideas and let more children with ADHD receive treatment happily.

　　China Youth Daily China Youth Network reporter Bai Hao Intern Pearl

After 24 years’ implementation, why has the Green Pass policy become the target of spitting？

Green Link was implemented in 1995, 24 years from now. This young post-90s generation has changed from a hot potato in those days, even if it can’t be said, from a burden reduction policy to a burden.

But it’s definitely not the Zhu Shazhi in the eyes of the freight driver, and the Bai Yueguang in the eyes. Especially since the implementation of the reduction and exemption of Green Link in 2005, there have been many contradictions and management problems in various provinces, and now the announcement of the New Deal of Green Link has actually fallen to the point of ridicule.

After 24 years' implementation, why has the Green Pass policy become the target of spitting?

The transportation of fresh agricultural products from the field to the dining table is essential. The implementation of the Green Pass policy connects the production and marketing links, which is related to the traffic efficiency and traffic cost of fresh agricultural products, and it is natural that the impact should not be underestimated.

The "Green Pass" policy itself is a policy to benefit the people. However, in the actual implementation process, due to the variety of fresh agricultural products and the objective existence of regional differences and seasonal differences, there are different standards for the reduction and exemption of products in the Catalogue of Fresh Agricultural Products in different provinces and seasons.

Finally, there are frequent standard fights, contradictions and disputes in various provinces, which have fallen to the point of ridicule.After 24 years' implementation, why has the Green Pass policy become the target of spitting?

In fact, in addition to standard fights, there are also many problems in the indispensable inspection link in the process of green link reduction and exemption. Due to the mixed loading and counterfeiting of Lutong, the overload and overrun are serious, and the inspection equipment is insufficient, which leads to time-consuming and laborious inspection, and it is inevitable to queue up for traffic jams.

It happens that the goods of Lutong are difficult to store and easy to be damaged. Once there are disputes over deterioration and loss in the middle, the freight driver not only has to take the freight but also compensate the owner for the loss. It is not worth the loss after a trip, and he can’t help complaining.

With the cancellation of inter-provincial toll stations, it is inevitable to popularize non-stop charging for high-speed ETC. The efficiency of high-speed traffic should be improved, and the green currency car should not be delayed, so adjustment is imperative. Recently, the three ministries and commissions announced the policy notice on further optimizing the "green channel" for the transportation of fresh agricultural products.

The unification of the Catalogue of Fresh Agricultural Products is a foregone conclusion. After unification, the contradictions and disputes arising from the differences in standards between regions can be reduced to a certain extent. At the same time, it is clear that the behavior of supplementing regions should be retired and standardized, and further standardization and rectification should be carried out to ensure the unity and standardization of the Catalogue of Fresh Agricultural Products.

After 24 years' implementation, why has the Green Pass policy become the target of spitting?

In the implementation of the reduction and exemption of Green Link, the innovation of management means is essential, and the system of advance booking+blacklist is the highlight after optimization. Advance booking can avoid the dispute of withholding payment first and then returning it. Inspectors can also plan their work in advance, saving time and improving inspection efficiency.

The establishment of the blacklist system can strengthen deterrence and avoid repeated crimes due to low illegal cost. It is convenient for drivers with good credit to get rid of drivers with bad credit in time, and it also has certain effect on standardizing and guiding the whole freight environment of Lvtong.

After 24 years' implementation, why has the Green Pass policy become the target of spitting?

In the past, it was time-consuming and laborious to inspect whether the loading capacity was up to standard or not on the spot in the process of green link policy reduction and exemption, and it was time-consuming and laborious to rely on the naked eye and manpower, so the popularization of intelligent technology and equipment was imperative.

Make an appointment in advance for unified inspection, popularize the installation of X-ray green pass inspection equipment and introduce green pass code to realize efficient inspection data sharing. In the process of landing, intelligent technology and management innovation are used to help the effective implementation of the green pass policy, so as to avoid the situation that the previous inspection efficiency is low and the traffic jam seriously leads to the deterioration of goods in the middle.

After 24 years' implementation, why has the Green Pass policy become the target of spitting?

The implementation of "Green Link" policy has been advancing with the times, following the pace of highway toll management, and there are inevitably many problems in the implementation of "Green Link" due to the imperfection of highway toll management.

After this optimization, the standards are unified, and the soil of group ridicule and the root of contradiction are eliminated to some extent. Coupled with the innovation of management means and the help of technical equipment, I believe that after the optimization of Lutong, it will usher in different vitality and different reputation. (Text/CardNo.:Lin Jin)

A film company in Guangdong illegally raised more than 200 million yuan, claiming crowdfunding to make movies.

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　　Yangcheng Evening News reporter Zhang Luyao, correspondent Zou Bang and Zhang Yitao reported that a film group company in Guangdong took advantage of the stunt that the film market is expanding rapidly and the company’s main business prospects are boundless, and engaged in illegal fund-raising activities in many places in the name of crowdfunding movies. In just a few months, it attracted more than 2,000 investors, involving more than 200 million yuan. Recently, the Economic Investigation Detachment of Guangzhou Public Security Bureau took action against the film group company engaged in illegal fund-raising activities in Guangzhou in the "Hurricane 2016" special action, and arrested it in Jingmen City and Panyu District of Hubei Province, bringing back seven people involved.

　　The reporter noticed that the company’s billboard claimed that the group has film companies, investment companies, entertainment planning companies, network technology companies, cultural media companies and even art training schools.

　　According to the police handling the case, the company promised that investors can get a dividend return of 3% of the investment amount every week (with a term of 2 years), and they can get a bonus of 0.9% of the investment amount directly recommended or indirectly recommended by the next investor every week.

　　They also absorbed investment funds from the public in Guangzhou, Dongguan, Beijing and other places by holding investment film publicity meetings, that is, the so-called crowdfunding investment in filming, with investment levels ranging from 50,000 yuan to 500,000 yuan. Through this viral promotion model similar to pyramid schemes, illegal fund-raising activities were carried out.

　　After the capital chain paying huge interest was unsustainable, the company continued to illegally solicit capital by means of equity investment (investment to obtain the company’s equity and guarantee the annual interest of 18%).

　　According to preliminary statistics, as of the time of the incident, the company has absorbed more than 2,000 investors, involving more than 200 million yuan.

　　The main suspect in the case confessed that 60% of the funds illegally absorbed by the company were used to pay huge interest, and the few main business investments that were really used for film and television drama shooting have not paid a penny back so far.

After school, 400,000 primary school students in Shijiazhuang are entrusted to ＂herd sheep＂ after school.

Children of Tokyo North Primary School in Yuhua District of Shijiazhuang learn calligraphy for free after school.

Children of Tokyo North Primary School in Yuhua District of Shijiazhuang learn calligraphy for free after school.

　 　 　 　Cctv news(Reporter Xu Hui) Children can enjoy free custody service on campus after school at around 4 pm. All parents need to do is fill out an application form. This move made Mr. Ning, a citizen of Shijiazhuang, give a thumbs up.

　　Mr. Ning’s son should be in the first grade of primary school in September this year. He and his lover both work in the company, and neither of them can help pick up and drop off the children. "Children leave school at around 4 pm every day, and our off-duty time is at 6 o’clock. What should the children do in these two hours? We are really worried about this."

　　Mr. Ning knows that there are off-campus care classes that can take care of children, but the expensive expenses are too much for Mr. Jeannin. "Spending money is on the one hand, and on the other hand, children are not safe in it and can learn something. These are also issues that my lover and I must consider."

　　Through communication with the school teacher, Mr. Ning learned that children can be placed in custody in the school after school. In the first week of school, the children brought back a piece of "Parents’ Understanding Paper on After-school Service for Primary School Students". Mr. Ning filled out the application according to the requirements of the form, and the problem of unattended children after school was solved. "This really gives me a heart attack. When children take care of us adults at school, we can rest assured and work with peace of mind."

　　According to Kang Jingcai, principal of Tokyo North Primary School in Yuhua District, Shijiazhuang City, among about 300 students in the school, more than 100 have signed up for after-school custody service. In order to enable children to learn useful skills in after-school trusteeship, Tokyo North Primary School has carried out extracurricular activities such as painting, calligraphy and basketball. "Providing in-school and out-of-class services for students of different grades can make children of each grade have teachers responsible for the whole process of learning and playing games."

Children of Tokyo North Primary School in Yuhua District of Shijiazhuang City kick shuttlecocks on campus after school.

Children of Tokyo North Primary School in Yuhua District of Shijiazhuang City kick shuttlecocks on campus after school.

　　Liu Qiansha, deputy director of the Basic Education Department of Shijiazhuang Education Bureau, said that in order to effectively solve the problem of unattended primary school students after school, ensure the safety of minors and effectively run a satisfactory education for the people, Shijiazhuang City adheres to the principle of public welfare and inclusiveness. Since 2016, free after-school services have been provided to primary school students in need. This service is mainly aimed at primary school students whose parents can’t pick them up and drop them off on time, and gives priority to the needs of groups in urgent need of services such as children from dual-income families, disabled children, left-behind children, migrant children from migrant workers and children with financial difficulties.

　　At present, the funds for the after-school service in the main urban area of Shijiazhuang are raised by the municipal and district governments, and are shared in the ratio of 6: 4, included in the annual budget and have been allocated. From 2015 to 2019, the financial investment of Shijiazhuang City increased from 1.5 million yuan to more than 23 million yuan, which provided sufficient financial guarantee for after-school service.

　　In the autumn semester of 2019, all 23 counties (cities, districts) in Shijiazhuang carried out after-school services for primary school students, covering 1,239 primary schools, accounting for 60.43% of the city’s primary schools, benefiting nearly 400,000 students.

　　Liu Qiansha said that in the next step, Shijiazhuang Education Bureau will continue to steadily promote the after-school service for primary school students, ensure the full coverage of after-school services for primary school students in need, actively meet the urgent needs of parents for after-school services, effectively solve parents’ worries, and truly make the policy of after-school services for primary school students benefit thousands of households.

Breaking through trillions of dollars for the first time, Beijing basked in last year’s housing provident fund account book.

　　CCTV News:Recently, Beijing Housing Provident Fund Management Center announced the 2017 Annual Report of Beijing Housing Provident Fund. The report shows that in 2017, the housing accumulation fund was 171.159 billion yuan, an increase of 20.942 billion yuan over the previous year and a year-on-year increase of 13.9%. By the end of 2017, the housing accumulation fund had accumulated 1,111.627 billion yuan, breaking through the trillion mark for the first time.

　　The number of depositors is increasing, and one in three people pays.

　　From the data of housing provident fund deposit, the number of paid-in units increased from 100,266 in 2014 to 158,263 in 2017, an increase of 57,997, with an increase of 57.8%. The number of paid-in employees increased from 5,713,900 in 2014 to 7,322,300 in 2017, an increase of 1,608,400, an increase of 28.1%. In 2017, there were 21.707 million permanent residents in Beijing, which means that one in every three people paid the housing provident fund.

　　More than 3 million people withdrew more than 126.1 billion from the housing provident fund last year.

　　Judging from the withdrawal situation, in 2017, a total of 3,257,300 employees paid housing provident fund withdrawal, accounting for 44.5% of the total number of employees who paid housing provident fund that year; A total of 126.191 billion yuan of housing provident fund was withdrawn, accounting for 73.7% of the housing provident fund collected in that year.

　　Nearly 90% of it is used for housing consumption.

　　Among the 3,257,300 employees, middle and low incomes accounted for 91.2%. The housing accumulation fund withdrawn by employees is mainly used for housing consumption expenses (mainly including buying houses, repaying the principal and interest of housing loans, renting houses, etc.). Of the amount withdrawn in 2017, 89.2% was used to support housing consumption, and only about 10% was used for non-housing consumption such as retirement and retirement withdrawal.

　　Housing provident fund personal loan business shrank by half.

　　In 2017, under the influence of "3.17 New Deal", the real estate market in Beijing continued to cool down, and the transaction volume decreased significantly compared with 2016. In 2017, the sales area of commercial housing in Beijing was 8.75 million square meters, down 47.8% from the previous year. Reflected in the personal loans of housing provident fund, the amount of loans issued in 2017 decreased by 50.1% year-on-year, shrinking by half, and the corresponding number of loans issued and the amount of loan recovery decreased, while the cumulative amount of loans issued, the cumulative number of loans issued and the loan balance slowed down.

　　Housing provident fund loan nine became the first set of housing.

　　Among the 57,818 housing units supported by Beijing’s housing provident fund personal loans in 2017, 64.2% were stock commercial housing, except 27.6% were affordable housing. Of these 57,818 housing units, 90.6% are first-time housing units and 68.0% are housing units with an area of less than 90 square meters. 75.5% of the people served by housing provident fund personal loans are under 40 years old (inclusive), 88.7% of the applicants are applying for housing provident fund personal loans for the first time, and 98.7% are middle-and low-income groups. It can be seen that the personal loan of housing provident fund mainly supports the rigid demand of middle-and low-income groups under the age of 40 to buy the first set of self-occupied small and medium-sized houses. Under the orientation of "houses are used for living, not for speculation", housing provident fund has played its due institutional role. (CCTV reporter Tigerson Yang)

The movie ＂The Lie Detector＂ only scored 2.7 points. Mary, you are very dangerous!


Special feature of 1905 film network As the saying goes, "a thief cries to catch a thief" is often also a "liar", especially for the film quality — — The film "Lie Detector" was released for 3 days, and Douban scored 2.7 points, which set a new low for the starring career score.


And this, from the last time Mary was dominated by bad movies, only three months have passed. In the fierce competition and frequent masterpieces this year, there is a movie whose reputation and rating seem so out of place. Yes, that’s her starring, and Douban scored 3.8.


Let’s go back to the lie detector. The trio of Mary,, and makes people think of another film a few years ago. Although other actors are different, they have the same low score.


At this moment, in this situation, a question quietly welled up in my mind: Mary, what’s wrong with you?

Sit tight in a comedy movie, doesn’t it smell good?


Since 2004, Mary has performed thousands of plays, and made her debut on the stage of the Spring Festival Gala with her sketch "Today’s Happiness 2". Since then, she has become a frequent visitor to the Spring Festival Gala, and has firmly held the position of Hua Dan, the master of Mahua FunAge, and the queen of stage plays.


In 2015, Mary’s Shen Ma teamed up with Douban, a high-scoring comedy film, and won the National Day title with a price of 1.448 billion yuan, which achieved a win-win situation at the box office. Mary herself was highly praised for her role as Ma Dongmei and won the title of "national daughter-in-law". She integrates humor and sincerity into the role, and leads the audience to find true love in laughter and tears with humorous performances that break through the image.


Two years later, while the iron was hot, Shen Ma once again took the title of the National Day file with a box office of 2.213 billion yuan, which also made Shen Ma take the position of a brother and a sister in domestic comedy.


A year later, Mary’s opera road has undergone a "subversive" change. In the remake of the film, she successfully played a strong woman who appeared to be vigorous and vigorous, but in fact she encountered Han Xiao, a victim of sexual assault in the workplace, and completed the film’s reflection on relevant social issues. As a result, Mary, whose expression became more and more serious on the big screen, kicked off the transition from "a comedy sister" to "a strong injured woman".


As Mary said in an interview with the film channel, "Comedy lets the audience know that there is an actress named Mary, and they think you are a comedian. It seems that all your next works must be related to comedy, but I am an actor, and you should create different types of roles as an actor."


Mary’s road to transformation started here, but it seems that the screenwriter is convinced of Mary’s role as a "strong woman", which makes this image of strong appearance and inner pain continue to this day — — Sunshine in "Sunshine Robber" has a childhood shadow of being ashamed of his mother, while Ma Xiaofan in "Lie Detector" has a heart that has been hurt by love. After a long illness, he became a doctor, and both of them were strong because of their injuries, and they suddenly became strongmen. However, this series of images are too repetitive with Han Xiao in "The Ring of Calls", so the market recognition has been declining all the way.


On the contrary, in the field of comedy that Mary is familiar with, her unique performance style of "Northeast Mary" and more professional team production have produced a series of comedy actresses who are loved by everyone but have their own characteristics. The most recent example is the chapter of Liang Ma, which was released in the National Day in 2020. On the vast black land, Shen Ma performed a scene of "Variations on Country Love" belonging to Mahua FunAge, and it also became a comedy in the five chapters of the film.


Coincidentally, Mary’s new comedy, which has not yet been released, also won the best film in Golden Goblet Awards at the 24th Shanghai International Film Festival this year, which is undoubtedly an excellent way for her to transform from a word-of-mouth actress to an art award winner.


So the question is, should Mary transform?


Play a role well all your life. Is there a problem?


It is true that while jumping out of the "comfort zone", Mary has also completed the new image challenge and broken through himself, but it has also exposed a reality — — Not suitable for all roles. From the current point of view, the most suitable is the comedy heroine with a "Northeast Mary" style. Fortunately, this position has not been shaken so far.


Since at this stage, Mary’s transformation is not the best choice, then, do actors really need to transform?


The most obvious example is Mary’s old partner, Shen Teng, who has honed the years from "military school grass" to "the first brother of China comedy movies" with a wrinkled face. He made his debut in the Spring Festival Evening at the age of 33, won the first season championship of "Happy Comedy" in one fell swoop three years later, and became famous all over the country with "goodbye mr. loser". Since then, he has starred in four phenomena of "Shameful Iron Fist" in succession. And successfully cooperated with Mary in last year’s My People My Homeland, and performed Shen Guanglin in this year’s Spring Festival file perfectly. Not only did he sit firmly on the throne of comedy, but he also partnered with who was popular, so the key point came — — Did he change his career? Has he changed? No, but he has become a contemporary "king of comedy".


After the actor, let’s talk about an actress who has a stable performance — — On the road of temperament, I am unique. As soon as she made her debut, she won the Golden Rooster and Hundred Flowers Best Supporting Actress awards with Beautiful Feet, and she was once addicted to the stage of drama performance. Since 2014, she has been waiting for the screen works to leave a glimpse. In the star-studded performance of the National Day in 2019, she stood out as the captain of the crew who was calm and resolute, and won two female matches, Baihua and Jinji, in succession last year.


Of course, being a successful actor is not a "stable" success. For example, actresses who were born in comedies in their early years have already successfully transformed into realistic actresses with their works. Only when a handsome actor ignores the image can he successfully transform into an actor in art cinema. In the early years, it was a jade-faced young man in the mainland, and in the middle of 2015, he was reborn with his unkempt father role, and finally kept the cloud open in the TV series "Chasing the Murder in a White Night", "Angry Xiangxi" and "Longling Mystery Cave".


If Pan Yueming was at a low point in his life and career, it needs to be transformed urgently; Hugh has accumulated a lot of money, and everything is only due to the east wind; Yao Chen and other actresses have a long-term vision and make the right changes and decisions at the right time.


For an actor, it is very rare to be able to play a role well all his life (such as a special actor who plays a great man, an actor with tough guy style, or "Oriental Chaplin" atsumi kiyoshi who plays Torajiro all his life and creates the most "longevity" comedy series in film history). If it is really necessary to change the stage, it is not too late to change it. It is not necessary to change it for the sake of change. If everything is not available, not only will the "East Wind" not be obtained, but it will also be.


The most complete egg! N things you need to know to interpret bumblebee.

Special feature of 1905 film network There is no doubt that this week’s release will refresh your understanding of the Transformers series.

　

Farewell to the indiscriminate bombing of "Bomb Shell", director Taravis Knight tells you how cured autobots are when they sell cute.

　

The film’s reputation in North America burst first, and rotten tomatoes were 93%!

　

What concept? It is more fresh than the last four michael bay series combined.

　

A summary of the scores of five Transformers rotten tomatoes

However, the freshness of the first film, which was born in 2007, was only 57%. Based on this, this "Bumblebee" achieved a gorgeous crush of word of mouth.

　

Domestic reputation is also good, Douban 7.5, Cat’s Eye 9.2, and the box office broke through the 100 million mark on the first day.

Whether the series is the best or not, every fan has a scale in his heart.

　

However, it is undeniable that, just like the heroine resurrects the bumblebee with a stun gun in the film, the director also injected a shot in the arm into this national series with a different family fun style.

Before the film was released, Xiao Dianjun also made a special trip to interview the four masters of the film:

If the film is not well made, it will go to Taravis Knight, the director who inherits hundreds of billions of dollars.

Hailee steinfeld, who was nominated for the Oscar for Best Female Actor at the age of 14.

WWE legendary wrestler, john cena of Chinese Saigao.

Lorenzo di Bonaventura, the helm of the Transformers series.

　

Listen to them tell you something you have to know before and after the "Bumblebee":

Back to G1

What is the position of Bumblebee in the deformed universe?

　 　 　 　 　

Draw a clear line with michael bay, starting with the timeline. This "Bumblebee" is set in 1987, and all the transformers are back to Generation 1. You don’t need to see the michael bay series to get into the play easily.

　

What is G1?

　

Generally speaking, it refers to the 98 episodes of Transformers animation that started broadcasting in 1984 and the 1986 Transformers movie.

　

In 1984, Hasbro company reached an agreement with TAKARA company of Japan to use their patents and images to develop American version of deformation toys. In order to cooperate with the sales of toys, Hasbro developed cartoons and three episodes of commercial cartoons.

　

Unexpectedly, after these three episodes of "advertisements" were broadcast, the response was overwhelming, and the legend of Transformers also kicked off.

　

In the late 1980s, Transformers animation was introduced to China, which became many childhood memories of the 1980s.

　

Therefore, this "Bumblebee" chose to return to the 1980s when the series was born, which is very reminiscent of killing. For the whole movie universe, it also means "soft restart".

　

"It is very important for me to return the Transformers to the time when they were really born. I still remember that when I first saw them on TV, it was the coolest thing I had ever seen. Pushing the time forward 20 years also gave us more creative space and we could make a new fuss about style." Director Taravis Knight said.

　

Transformers in Bumblebee Return to Classic G1 Style

Asked about the future development direction of the bumblebee series, the producers who are good at secrecy naturally played "Tai Chi". "It depends on word of mouth and box office performance!"

　

However, the producer said with great certainty that a sequel to the Transformers series and an animated film have been written, and the story of the sequel to the Bumblebee series will be relatively independent and will not cross the main series for the time being.

　

Next page: Deep analysis of eggs in Cybertron War

The Ministry of Industry and Information Technology abolished and adjusted a number of mandatory standards for industrial communications.

According to the State Council’s work requirements of deepening standardization reform and streamlining mandatory standards, the Ministry of Industry and Information Technology recently carried out a comprehensive clean-up of the mandatory industry standards of industrial communication industry, and decided to abolish 150 mandatory industry standards such as davit poles and adjust 354 mandatory industry standards such as Hexamethylene to recommended industry standards. This conclusion has been deliberated and agreed by the the State Council Inter-Ministerial Joint Conference on Standardization Coordination and Promotion.

Recently, the Ministry of Industry and Information Technology issued an announcement announcing the abolition and adjustment of a number of mandatory standards for industrial communications. The announcement pointed out thatAccording to the State Council’s Work Plan for Deepening Standardization Reform and the State Council’s General Office’s Work Plan for Integrating and Streamlining Compulsory Standards, the Ministry of Industry and Information Technology has carried out a comprehensive clean-up of compulsory industry standards in industry and communications. After evaluation and item-by-item review, the Ministry of Industry and Information Technology put forward the conclusion of integration and simplification, which has been reviewed and agreed at the third plenary session of the the State Council Inter-ministerial Joint Conference on Standardization Coordination and Promotion (hereinafter referred to as the Joint Conference).

According to the requirements of the Notice of the Joint Conference Office on Printing and Distributing the Conclusions on the Integration and Simplification of Compulsory Standards (National Standards Committee Comprehensive Letter [2017] No.4), the Ministry of Industry and Information Technology decided to abolish 150 compulsory industry standards (see Annex 1 for details), including 2 in shipbuilding industry, 1 in textile industry, 43 in chemical industry, 2 in pharmaceutical equipment industry, 29 in machinery industry, 58 in light industry and civil explosion industry. It is decided to adjust 354 compulsory industry standards such as Hexamethylene to recommended industry standards (see Annex 2 for details), including 129 in chemical industry, 9 in metallurgical industry, 31 in building materials industry, 1 in rare earth industry, 4 in machinery industry, 23 in pharmaceutical equipment industry, 13 in shipbuilding industry, 67 in light industry, 42 in textile industry, 2 in packaging industry and 22 in civil explosion industry.

Annex 1: List of abolished compulsory industry standards (150 items)

Annex 2: List of mandatory industry standards converted into recommendations (354 items)

The Middle East is at the most chaotic moment in 50 years： the Palestinian-Israeli conflict has triggered a humanitarian crisis.

October 7th marks one year since the new round of Palestinian-Israeli conflict broke out. On the same day last year, the Palestinian Islamic Resistance Movement (Hamas) launched a military operation called "Al-Aqsa Flood", which fired a large number of rockets at Israel and carried out ground attacks, prompting Israel to declare a state of war and fight back. The tragedy caused by the conflict is particularly obvious in Gaza. According to the data of local health department, as of October 5, there have been more than 150,000 Palestinian casualties, including 41,000 deaths, accounting for 33.1% of children and 18.3% of women, and even more than 700 infants have died. The Lancet magazine estimated that the actual death toll may have exceeded 186,000, which far exceeds the civilian casualties in previous conflicts in the Middle East.

The turmoil in the Middle East has a long history and has experienced many wars. However, the tragic degree and humanitarian crisis of this round of Palestinian-Israeli conflict have never been seen before, and the conflict has spread to Lebanon, Syria, Yemen and Iran. Exploring the reasons behind it, in addition to historical grievances, this round of conflict presents new characteristics, making it difficult to contain the escalation of violence. In the past, Israel’s actions were limited to a certain extent by the international political structure, but the current lack of international balance and the right-wing political tendency in Israel have led to more radical policies. At the same time, changes in the balance of power in the Middle East, such as the easing of relations between Saudi Arabia and Iran and Syria’s return to the Arab League, have made Israel feel threatened, and the decline of American influence has further prompted it to take tough measures.

Although the United Nations and other international organizations have intervened many times to try to ease the situation, including giving Palestine more rights on the international stage, the ruling of the International Court of Justice and the resolution of the United Nations General Assembly, they have failed to effectively restrain Israel’s actions, but have aggravated regional tensions, especially Israel’s potential attack plan on Iran, making the prospects for peace increasingly slim.

This persistent cycle of violence highlights the inadequacy of the current international security order and the lag of security concepts. To break the vicious circle of fighting violence with violence, all parties to the conflict, especially the dominant party, need to realize that real security should be based on equality and sustainability, rather than sacrificing the security of other countries. This is not only the key to resolving the Palestinian-Israeli conflict, but also the only way to achieve long-term peace in the Middle East.

The main respiratory syncytial virus infected in winter finally has a preventive medicine.

Respiratory syncytial virus (RSV) is one of the most frequently mentioned respiratory infectious diseases or pathogens in the winter of 2023.

Last November, at the press conference organized by National Health Commission, RSV was mentioned many times. On November 13, 2023, Wang Quan, chief physician of Beijing Children’s Hospital, said, "On the whole, virus is still the most common pathogen of respiratory tract infection in children, including influenza virus, rhinovirus, adenovirus and respiratory syncytial virus." On November 26, 2023, Mi Feng, spokesperson of the National Health and Wellness Commission and deputy director of the Propaganda Department, once pointed out that "monitoring shows that recently, respiratory infectious diseases are mainly influenza. In addition, rhinovirus, mycoplasma pneumoniae, respiratory syncytial virus, adenovirus, etc. "

RSV is a negative single-stranded RNA virus belonging to the genus Pneumonia of Paramyxoviridae. It is named because it is related to respiratory tract infection and can fuse infected cells. Moreover, RSV is the pathogen of acute respiratory infection after influenza.

According to a prospective surveillance study on all-age patients with acute respiratory infection in China from 2009 to 2019, the etiology and epidemiological characteristics of about 231,000 patients were analyzed. As a whole, influenza (28.5%), RSV(16.8%) and rhinovirus (16.7%) were the most common virus pathogens. Children and the elderly are the key people infected with RSV. Among them, in children under 5 years old, the positive rate of RSV detection exceeds that of influenza and rhinovirus, and RSV has become the most common virus pathogen that causes respiratory tract infection in children.

On January 2nd, AstraZeneca and Sanofi jointly announced that the long-acting monoclonal antibody Nirsevimab/Nisevimab was officially approved for marketing in National Medical Products Administration, China, to prevent lower respiratory tract infection (LRTI) caused by RSV in newborns and infants. This also fills the gap that there is no medicine for preventing RSV infection in infants in China.

It is worth noting that nisevimab is the first and only approved preventive measure to protect infants from RSV infection in China, covering healthy full-term infants, premature infants and infants susceptible to severe RSV infection due to special health conditions. In addition, nisevimab can achieve the effect of continuous protection for 5 months with one injection, that is, a typical RSV infection season (November-April in the northern hemisphere, totaling 5-6 months).

AstraZeneca and Sanofi revealed that nisevimab is expected to be listed in China during the RSV infection season in 2024-2025. Previously, nisevi monoclonal antibody had been approved in the European Union and the United States. The listing applications submitted by nisevimab in Japan and other markets are also under review.

At present, there are two main ways to prevent RSV infection: vaccination and drug prevention. In terms of drugs to prevent infection, infants can prevent RSV infection by injecting palizumab or nisevimab, while adults have no related RSV preventive drugs at present.

Both palizumab and nisevimab are products of AstraZeneca. Among them, palizumab is the first drug approved for the prevention of RSV infection in children in the world. It was approved for marketing in the United States in 1998 and has not been approved for marketing in China yet. The population covered by this drug is small, and the EU only recommends the use of this drug for premature infants within 6 months and under 35 weeks after birth, children with bronchopulmonary dysplasia (BPD) who need treatment in the past 6 months, and children with congenital heart disease (CHD) who are over 24 months old.

Moreover, compared with only one injection of nisevizumab in an RSV epidemic season, palizumab needs to be injected once a month in the RSV epidemic season, and the drug price is high.

In terms of vaccines, in 2023, the FDA approved the listing of RSV vaccines from Pfizer and GlaxoSmithKline. Infants within 6 months can take the initiative to inoculate Pfizer bivalent RSV vaccine Abysvo at 24-36 weeks of pregnancy to prevent RSV-related lower respiratory diseases, while people over 60 years old can be inoculated with GlaxoSmithKline’s RSV vaccine Arexvy or Pfizer bivalent RSV vaccine Abysvo for prevention, and there is no relevant RSV vaccine on the market for other age groups.

At present, GlaxoSmithKline’s RSV vaccine has been approved for clinical trials in China and has reached cooperation with domestic pharmaceutical companies. On June 19th, 2023, China National Medical Products Administration Drug Evaluation Center (CDE) official website announced that the RSV vaccine (AS01E adjuvant system) declared by GlaxoSmithKline had obtained implied permission for clinical trials and was suitable for active immunization to prevent lower respiratory diseases in adults aged 60 and above caused by RSV-A and RSV-B subtypes. On October 8, 2023, GlaxoSmithKline reached a strategic cooperation with Zhifei Bio, and Zhifei Bio won the priority agency right of RSV vaccine in mainland China.

It is worth mentioning that not long ago, the only RSV vaccine giant started a patent war. In August 2023, GlaxoSmithKline filed a patent lawsuit against Pfizer, claiming that Pfizer’s RSV vaccine Abrysvo infringed four patents of GlaxoSmithKline’s vaccine Arexvy. If GlaxoSmithKline wins the case, Pfizer will be permanently banned from selling and producing RSV vaccine in the United States in the future.

RSV is considered as the next field with a market of 10 billion dollars. Minsheng Securities Research Report shows that the overall global market size of RSV drugs (including preventive and therapeutic drugs) is expected to increase from $1.8 billion in 2020 to $12.8 billion in 2030, with a compound annual growth rate of 21.4%.

The market potential of RSV can be seen from the sales of products that have been listed. The aforementioned two RSV vaccines, Abrysvo of Pfizer and Arexvy of GlaxoSmithKline, achieved revenue of $375 million and $870 million respectively in the first quarter after being approved for marketing. Insight database shows that even palizumab, which has extremely limited coverage and short effect duration, has reached a sales peak of $1.6 billion in the past decade.

Many domestic pharmaceutical companies have also joined the development of the 10 billion blue ocean market. From the domestic research and development of RSV vaccine, many pharmaceutical companies, such as watson biological/Blue Magpie Bio, Unacon, Zhifei Bio, Clover Bio, Aidiweixin, participated in the research and development of RSV vaccine, but most of them are still in the early stage. Among them, the research and development progress of Aidiweixin is relatively fast, and its product ADV110 is in the second clinical stage; It is estimated that the phase II study will be extended from the elderly group to the infant group in 2024, aiming at protecting children aged 6 months to 5 years and the elderly over 65 years old.

According to the research of children’s RSV preventive drugs, TNM001 of Tylenol Mai Bo is in phase II/III clinical research, and RB0026 of Ruiyang Biotechnology is in phase I clinical trial. In addition to the products already on the market, the fastest research and development progress in the world is Clesrovimab of Merck, which has been in phase III clinical research.

Judging from the drugs under research for the treatment of children’s RSV infection, the domestic pharmaceutical company Aike Baifa AK0529 has submitted an application for NDA registration, and the progress is leading. AK0529 is an oral drug, which is suitable for children from birth to 24 months old. In addition, RV521 from Pfizer and EDP-938 from Enanta are under research all over the world, all of which are oral drugs, suitable for children aged from January to 36 months and 28 days to 36 months respectively. As of October 20, 2023, these two products are in phase II clinical trials.